Role of Jak Kinases and STATs in Cytokine Signal Transduction
- 1 April 2001
- journal article
- review article
- Published by Springer Nature in International Journal of Hematology
- Vol. 73 (3), 271-277
- https://doi.org/10.1007/bf02981951
Abstract
The Janus family tyrosine kinase—signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins; after ssactivation, however, they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.Keywords
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