The Structure-Action Relationships of the Choline Group

Abstract

A synthesis and critique of work in the field is presented and the hypothesis made that the intensity of the muscarine-like action of members of the choline group is determined by the dimensions of the cationic head and the chain groups of the drug molecules, suggesting templet action between drug and some macromolecular structure in cell as the basis of pharmacologic effectiveness. Relationships for nicotine-like actions are obscure.