IMMUNOLOGICAL DIFFERENCES IN HUMAN ISOFERRITINS - IMPLICATIONS FOR IMMUNOLOGICAL QUANTITATION OF SERUM FERRITIN

Abstract

Immunologic differences in several tissue isoferritin populations were investigated using antibodies developed in rabbits against human liver ferritin and in quinea pigs against HeLa cell ferritin. The quantity of ferritin measured by radioimmunoassays is markedly affected by the isoferritin and subunit composition of the ferritin sample as well as by the nature of the antiferritin antibodies. Possible applications for the selective quantitation of different serum ferritin populations are discussed.