Aflatoxin B 1 : Binding to DNA in vitro and Alteration of RNA Metabolism in vivo
- 25 March 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 151 (3717), 1539-1541
- https://doi.org/10.1126/science.151.3717.1539
Abstract
Aflatoxin B1 binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B1 may be direct results of the affinity of this agent for DNA.This publication has 9 references indexed in Scilit:
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