Studies on Abnormal Hemoglobins
Open Access
- 1 May 1951
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 6 (5), 429-435
- https://doi.org/10.1182/blood.v6.5.429.429
Abstract
By means of fractional denaturation, it is possible to follow the progress of alkaline degradation of resistant hemoglobins. A characteristic pattern was established for the fetal compound. The alkali resistant hemoglobin fractions in Mediterranean anemia and in some acquired hematologic conditions (acute leukemia and chronic aregenerative anemia) behaved like the fetal pigment. In sickle cell anemia only 4 out of 11 specimens were found to have fetal hemoglobin, whereas the others seem to have a fetal-like compound. Similarly, in 2 members of one family with hereditary spherocytosis, the resistant pigment was also fetal-like. The significance of these findings for the hypothesis that the resistant hemoglobin fractions in these disorders represent either a continuation or a reactivation of the production of the embryonic pigment is discussed.This publication has 5 references indexed in Scilit:
- Studies on Abnormal HemoglobinsBlood, 1951
- The free amino groups of haemoglobinsBiochemical Journal, 1948
- SPECTROPHOTOMETRIC STUDIES .14. THE CRYSTALLOGRAPHIC AND OPTICAL PROPERTIES OF THE HEMOGLOBIN OF MAN IN COMPARISON WITH THOSE OF OTHER SPECIES1946
- Oxygen transport of the fœtal and maternal blood during pregnancyThe Journal of Physiology, 1936
- The occurrence of several kinds of hæmoglobin in human bloodThe Journal of Physiology, 1935