5-HT1A autoreceptor desensitization by chronic ultramild stress in mice
- 1 November 1999
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 10 (16), 3369-3374
- https://doi.org/10.1097/00001756-199911080-00021
Abstract
ELECTROPHYSIOLOGICAL and biochemical approaches were used to assess possible changes in central 5-HT neurotransmission in mice that had been subjected to chronic ultramild stress for 8 weeks. This treatment produced a significant decrease in the potency of the 5-HT1A agonist ipsapirone to inhibit the electrical activity of serotoninergic neurons in the dorsal raphe nucleus, without modifying 5-HT1A receptor binding in various brain areas. These data demonstrate that chronic ultramild stress triggers a long term and durable functional desensitization of somatodendritic 5-HT1A autoreceptors in mice.Keywords
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