Insulin analogues
- 1 February 1997
- journal article
- review article
- Published by Informa UK Limited in Postgraduate Medicine
- Vol. 101 (2), 58-70
- https://doi.org/10.3810/pgm.1997.02.157
Abstract
For years, it has been recognized that "reasonable" control of blood glucose levels reduces the acute complications of diabetes mellitus. Recent studies have conclusively shown that strict glycemic control reduces the appearance and progression of chronic complications. Thus, strict glycemic control is the most salient goal of insulin therapy. Insulin regimens that closely mimic physiologic insulin secretory patterns have been inadequate because of limitations imposed by the pharmacokinetic profiles of commercially available preparations. The newer insulin analogues, both rapid-acting and long-acting, have more appropriate pharmacokinetic profiles. Lispro (Humalog) is the first human insulin analogue to be approved in the United States. Its pharmacokinetic and pharmacodynamic profile makes it amenable for use before meals. The search for long-acting and hepatospecific analogues continues.Keywords
This publication has 10 references indexed in Scilit:
- Insulin Lispro: Its Role in the Treatment of Diabetes MellitusAnnals of Pharmacotherapy, 1996
- Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year studyDiabetes Research and Clinical Practice, 1995
- Hyperglycemie and Microvascular and Macrovascular Disease in DiabetesDiabetes Care, 1995
- Improving Insulin Therapy: Achievements and ChallengesHormone and Metabolic Research, 1994
- Preparation of an Insulin with Improved Pharmacokinetics Relative to Human Insulin through Consideration of Structural Homology with Insulin-Like Growth Factor IHormone Research, 1994
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptakeDiabetes/Metabolism Research and Reviews, 1992
- Monomeric Insulins and Their Experimental and Clinical ImplicationsDiabetes Care, 1990
- NovoSol Basal: pharmacokinetics of a novel soluble long acting insulin analogue.BMJ, 1989
- The Discovery of InsulinPublished by Springer Science and Business Media LLC ,1982