Experimental Studies on the Pathogenesis and Prophylaxis of Stroke in Stroke-prone Spontaneously Hypertensive Rats(SHR) : (1) Quantitative Estimation of Cerebrovascular Permeability

Abstract

The cerebrovascular permeability quantitatively determined by the retention of ¹³¹I-human albumin in the perfused brains was increased in SHR, especially in stroke-prone SHR compared with normotensive Wistar-Kyoto, and confirmed the macroscopical or microscopical findings on the leakage into the brain of trypan blue or peroxidase injected intravenously 2 to 3 hours before sacrifice. The localization of increased vascular permeability in SHR cor-responded to the predilection sites of cerebral hemorrhage or softening, which developed likely following the increased cerebrovascular permeability.