STUDIES ON NEOPLASMS WITH THE AID OF RADIOACTIVE PHOSPHORUS. II. THE PHOSPHORUS METABOLISM OF THE NUCLEOPROTEIN, PHOSPHOLIPID AND ACID SOLUBLE FRACTIONS OF NORMAL AND LEUKEMIC MICE

Abstract

The manner in which a single dose of radioactive P is handled over a period of 7 days by the tissues of 50 normal and 50 leukemic mice was detd. Leukemic infiltration is accompanied by an increase of several-fold in the uptake and retention of radioactive P by the nucleoprotein and acid-soluble fractions of liver, spleen and lymph nodes. The phospholipid metabolism of spleen and lymph nodes is affected to only a limited extent by leukemic infiltration, while that of liver is depressed only during the 1st day after the adm. The whole body retention of P administered to leukemic mice is higher than that of normal mice.