Effect of 22,25-Diazacholestanol on Synthesis of Cholesterol by Rat Liver Homogenates
- 1 June 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 116 (2), 537-539
- https://doi.org/10.3181/00379727-116-29299
Abstract
Summary In rat liver homogenates 22,25-diazacholestanol blocked to the same extent the incorporation into cholesterol of 2-C14-acetate, 2-C14-mevalonate and of 26,27-C14-desmosterol. Thus, direct evidence is provided for a triparanol-like interference with hepatic cholesterogenesis in vitro. This is in agreement with the finding of appreciable desmosterol levels in humans and rats treated with 22,25-diazacholestanol per os.Keywords
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