PASSIVE CUTANEOUS ANAPHYLAXIS IN GUINEA-PIG WITH RABBIT ANTIBODIES AGAINST SYNTHETIC POLYPEPTIDES
- 1 January 1964
- journal article
- research article
- Vol. 7 (2), 142-+
Abstract
The reactions of synthetic polypeptides with their antibodies may be followed by passive cutaneous anaphylaxis, but not by the reverse technique. The reactions were optimal when 18 hours elapsed between the injection of the serum and that of the antigen. Materials which were non-immunogenic as followed by the precipitin test, were shown to be non-immunogenic also by PCA technique. The antisera to various synthetic polypeptide antigens cross-reacted with many chemically related polypeptides. As little as 0.12 [mu]g. of antibody could be detected in 1 ml. of diluted antisera by the PCA technique.Keywords
This publication has 11 references indexed in Scilit:
- NATURE OF ANTIGENIC DETERMINANTS IN PROTEINS AND SYNTHETIC POLYPEPTIDES*Annals of the New York Academy of Sciences, 1963
- Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosineBiochemical Journal, 1962
- ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS)The Journal of Experimental Medicine, 1962
- Antigenicity of Polypeptides (Poly-α-Amino Acids). IIThe Journal of Immunology, 1962
- A specific synthetic polypeptide antigenBiochimica et Biophysica Acta, 1960
- Reverse passive cutaneous anaphylaxis in the guinea pig with horse, sheep or hen antibodies.1960
- Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction.1958
- Passive Reversed Cutaneous Anaphylaxis to Protein AntigensInternational Archives of Allergy and Immunology, 1955
- Quantitative Studies on Passive Cutaneous Anaphylaxis in the Guinea Pig and Its Relationship to the Arthus PhenomenonThe Journal of Immunology, 1953
- [New method of dosage of anaphylactic antibodies and its relation to the nitrogen of the antibody].1951