The smallest genome RNA segment of influenza virus contains two genes that may overlap.
- 1 August 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (8), 3790-3794
- https://doi.org/10.1073/pnas.76.8.3790
Abstract
The genome of influenza virus consists of eight segments of single-stranded RNA, each of which encodes a different polypeptide. In addition to the eight recognized gene products, the virus specifies a distinct smaller nonstructural polypeptide (NS2), which is translated from a separate species of virus-specific mRNA. The location on the virus genome of the gene encoding this polypeptide was investigated by hybridization of the NS2 mRNA with isolated subgenomic RNA species, and by correlation of the inheritance of a strain-specific NS2 with inheritance of particular genome RNA segments during recombination between two different virus strains. The genetic information for NS2 was found to reside in the smallest genome RNA segment of the virion, which also encodes the NS1 polypeptide. Considering the sizes of the molecules involved, it is likely that the coding sequences for the two polypeptides overlap.This publication has 34 references indexed in Scilit:
- Polypeptides specified by the influenza virus genome 3. Control of synthesis in infected cellsVirology, 1979
- Transfer of 5′-terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitroProceedings of the National Academy of Sciences, 1979
- Temperature-sensitive mutants of fowl plague virus: Isolation and genetic characterizationVirology, 1979
- Genetic recombination between two strains of fowl plague virus: Construction of genetic mapsVirology, 1979
- Evidence for a ninth influenza viral polypeptideVirology, 1978
- Nucleotide sequences at the 5′ termini of influenza virus RNAs and their transcriptsNucleic Acids Research, 1978
- A single gene determines the host range of influenza virusNature, 1977
- Correlation between RNA fragments of fowl plague virus and their corresponding gene functionsVirology, 1976
- Synthesis of influenza virus proteins in infected cells: Translation of viral polypeptides, including three P polypeptides, from RNA produced by primary transcriptionVirology, 1976
- Polypeptides specified by the influenza virus genomeVirology, 1976