Griseofulvin Inhibition of Polymorphonuclear Leucocyte Chemotaxis in Boyden Chambers

Abstract

Griseofulvin inhibited the chemotaxis of polymorphonuclear leucocytes (PMNs) in vitro in the concentration range 0.1-1.0 μg/ml, i.e. at concentrations comparable to those obtained in serum during peroral treatment with griseofulvin. It is suggested that PMN chemotaxis is inhibited by griseofulvin interference with the redistribution of cytoplasmic microtubules, which is thought to be essential in the direction-finding of PMNs during chemotaxis. Furthermore, it is suggested that the griseofulvin inhibition of PMN chemotaxis - together with the previously known pharmacodynamic properties of griseofulvin - may provide the rationale for griseofulvin therapy in PMN-mediated tissue injury of the gut.