Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
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- 2 April 2006
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 9 (5), 602-604
- https://doi.org/10.1038/nn1678
Abstract
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.Keywords
This publication has 15 references indexed in Scilit:
- Regulation of Synaptic Strength and AMPA Receptor Subunit Composition by PICK1Journal of Neuroscience, 2004
- Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptorsNature Neuroscience, 2004
- A Developmental Switch of AMPA Receptor Subunits in Neocortical Pyramidal NeuronsJournal of Neuroscience, 2002
- Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal NeuronsCell, 2001
- Differential Mechanisms of Transmission at Three Types of Mossy Fiber SynapseJournal of Neuroscience, 2000
- Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain InteractionScience, 2000
- Afferent-specific innervation of two distinct AMPA receptor subtypes on single hippocampal interneuronsNature Neuroscience, 1998
- Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel blockNeuron, 1995
- Block of native Ca(2+)‐permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification.The Journal of Physiology, 1995
- Intracellular spermine confers rectification on rat calcium‐permeable AMPA and kainate receptors.The Journal of Physiology, 1995