Die intrazelluläre Verteilung von embryonalem Hämoglobin in roten Blutzellen menschlicher Embryonen

Abstract

By acid elution at pH 2.9 it was possible to show a nonelutable blood pigment in blood smears of human embryos of 2.4-10 cm length. Under the same conditions blood smears of newborn infants were completely eluted. The finding was correlated with the presence of Hb [hemoglobin] Gower 1 and 2 in starch gel electrophoresis. The nonelutable pigment was found mainly in megaloblasts, but some normocytes were also seen containing it. There were some megaloblasts, which were completely or partly eluted. It suggested that the nonelutable blood pigment represents embryonic hemoglobin (Hb Gower 1 and 2).