A novel protein phosphatase 2C family member (PP2Cζ) is able to associate with ubiquitin conjugating enzyme 91
- 19 February 2003
- journal article
- Published by Wiley in FEBS Letters
- Vol. 538 (1-3), 197-202
- https://doi.org/10.1016/s0014-5793(03)00153-4
Abstract
In this study we have cloned a novel member of mouse protein phosphatase 2C family, PP2Cζ, which is composed of 507 amino acids and has a unique N-terminal region. The overall similarity of the amino acid sequence between PP2Cζ and PP2Cα was 22%. On Northern blot analysis PP2Cζ was found to be expressed specifically in the testicular germ cells. PP2Cζ expressed in COS7 cells was able to associate with ubiquitin conjugating enzyme 9 (UBC9) and the association was enhanced by co-expression of small ubiquitin-related modifier-1 (SUMO-1), suggesting that PP2Cζ exhibits its specific role through its SUMO-induced recruitment to UBC9.Keywords
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