Ferromagnetic particles as contrast agents for magnetic resonance imaging of liver and spleen

Abstract

Particles of magnetite, Fe₃O₄, accumulate preferentially in the liver and spleen after intravenous injection. Their magnetic fields drastically decrease echo intensities in spinecho proton magnetic resonance imaging sequences, as demonstrated by experiments on dogs injected with 10 mg/kg of 0.05-μm particles. © 1986 Academic Press, Inc.