Screening hallucinogenic drugs: Systematic study of three behavioral tests
- 1 January 1975
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 42 (2), 163-171
- https://doi.org/10.1007/bf00429548
Abstract
The effects of several hallucinogenic and non-hallucinogenic drugs have been studied on three behavioral tests proposed as useful indexes of hallucinogenic activity: “head-twitching” in mice, defecation in an open-field, and suppression of responding on a differential reinforcement of low rates (DRL) schedule of reinforcement. According to the original propositions, after administration of hallucinogenic agents the frequency of head-twitches would increase in mice, the defecation of rats in an open field would decrease without consistent change in ambulation, rearing and grooming, and the responding of rats on a DRL schedule would yield a typical cumulative record pattern. It was found that the head-twitch test was sensitive to mescaline and LSD-25, but not to δ9-THC or to myristicin and elemicin. Besides, the data on interobserver agreement suggested there is a high degree of subjectivity involved in assessing this response. In the open-field test, non-hallucinogenic drugs such as chlorpromazine and apomorphine fell into the hallucinogenic pattern proposed. In addition, the post-injection interval selected seemed to critically affect defecation scores. The DRL “hallucinogenic” pattern occurred nonspecifically after administration of hallucinogenic and non-hallucinogenic drugs. It was concluded that the three tests have limited value for screening purposes.Keywords
This publication has 29 references indexed in Scilit:
- Comparative Studies in Man and in Laboratory Animals on ▵8- and ▵9-trans-TetrahydrocannabinolPharmacology, 1973
- Evidence for the Biogenic Formation of Amphetamine Derivatives from Components of NutmegPharmacology, 1973
- Effects of l-Δ1-Tetrahydrocannabinol on Temporally Spaced Responding and Discriminated Sidman Avoidance Behaviour in RatsNature, 1971
- Effects of Hallucinogenic and other Drugs on the Nest-building Behaviour of MiceNature, 1970
- Mescaline and other O-methylated β-phenylethylamines: Intrastriatal induction of tremor in ratsBrain Research, 1969
- Behavioural Models of PsychosisThe British Journal of Psychiatry, 1969
- Behavioural Effects of some Morphine Antagonists and Hallucinogens in the RatNature, 1968
- Hyperthermic effects of some tryptamine derivatives in relation to their behavioural activityInternational Journal of Neuropharmacology, 1967
- The relative potencies of psychotomimetic drugsLife Sciences, 1965
- Some properties of the warning stimulus in avoidance behavior.Journal of Comparative and Physiological Psychology, 1955