Comparative Antiproliferative Efficacies of Human and Interferons

Abstract

The cell growth inhibitory efficacies of preparations of human α and γ interferons (IFNs) have been tested on a variety of human cell lines. Human IFN-γ was found to be more effective at inhibiting the growth of HeLa and U-amnion cells than was human IFN-α. The Daudi cell line, on the other hand, which exhibits a strong anticellular effect in response to treatment with human IFN-α, was found to be relatively insensitive to the anticellular effect of human IFN-γ, as were a variety of other lymphoid cell lines. The inability of the IFN-γ to inhibit the growth of the Daudi cells is paralleled by its inability to induce the synthesis of proteins observed to be synthesized in these cells in response to IFN-α.