HISTOCOMPATIBILITY DIFFERENCE BETWEEN C3HfeB/HeN AND C3H/HeN MICE: TUMOUR INDUCED IN C3HfeB/HeN MICE EXPRESSES C3H/HeN‐ASSOCIATED ALLOANTIGEN
- 1 August 1978
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 5 (4), 255-260
- https://doi.org/10.1111/j.1744-313x.1978.tb00653.x
Abstract
A transplacentally induced lung tumour of C3HfeB/HeN mouse origin expresses, as a tumour-associated antigen, a normal tissue component of strain A mice. The genetic locus coding for this alloantigen has been shown to be linked to the H-2 major histocompatibility complex. In the present study we demonstrate that this antigen is also expressed on normal tissues of C3H/HeN mice. Skin grafts exchanged between C3HfeB/HeN and C3H/HeN mice are reciprocally rejected at approximately 3 weeks after grafting. C3HfeB/HeN mice were derived from C3H/HeN mice in 1945. These strains have apparently deviated since then in their genetic regulation of the expression of the MHC-linked genetic locus. The finding of the C3H/HeN-associated antigen on a C3HfeB/HeN mouse-derived lung tumour indicates that this deviation is reversible.Keywords
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