Synthesis of new cephamycin derivatives and a novel rearrangement between isothiazolethioacetamides and 1,3-dithietanecarboxamides.

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Abstract
A novel intramolecular rearrangement of isothiazolethioacetamides into 1,3-dithietanecarboxamides is described, together with the synthesis of a new cephamycin derivative (YM-09330) having a 1,3-dithietane structure at the 7.beta.-position. This compound showed strong antibacterial activity, especially against gram-negative organisms.