Molecular regulation of kidney development: is the answer blowing in the Wnt?
Open Access
- 7 June 2007
- journal article
- review article
- Published by Springer Nature in Pediatric Nephrology
- Vol. 22 (11), 1825-1838
- https://doi.org/10.1007/s00467-007-0504-4
Abstract
Development of the metanephric kidney is a complicated process regulated by reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate tubule formation and epithelial branching morphogenesis. Over the past several years, several studies have suggested that Wnt signaling is involved in multiple aspects of normal kidney development as well as injury response and cancer progression. We will review these data here.Keywords
This publication has 115 references indexed in Scilit:
- Diversity of LEF/TCF action in development and diseaseOncogene, 2006
- Catenins: Keeping Cells from Getting Their Signals CrossedDevelopmental Cell, 2006
- Jun NH 2 -terminal kinase (JNK) prevents nuclear β-catenin accumulation and regulates axis formation in Xenopus embryosProceedings of the National Academy of Sciences, 2006
- Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane ProteinCell, 2006
- Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling CellsCell, 2006
- Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor ContextPLoS Biology, 2006
- Defective planar cell polarity in polycystic kidney diseaseNature Genetics, 2005
- THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASEAnnual Review of Cell and Developmental Biology, 2004
- Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signalingGene, 2002
- Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationNature, 2000