Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
- 31 August 1979
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 205 (4409), 929-932
- https://doi.org/10.1126/science.112679
Abstract
Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.Keywords
This publication has 10 references indexed in Scilit:
- Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis ratesBrain Research, 1979
- Regional distribution of catecholamines in monkey cerebral cortex, evidence for a dopaminergic innervation of the primate prefrontal cortexNeuroscience Letters, 1978
- Catecholamines in neocortex of rhesus monkeys: regional distribution and ontogenetic developmentBrain Research, 1977
- Norepinephrine-Dopamine Interactions and BehaviorScience, 1977
- Intracranial injections of 6-OHDA. Comparison of catecholamine-depleting effects of different volumes and concentrationsPharmacology Biochemistry and Behavior, 1976
- Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic DrugsScience, 1976
- Analysis of the delayed-alternation deficit produced by dorsolateral prefrontal lesions in the rhesus monkey.Journal of Comparative and Physiological Psychology, 1971
- Localization of function within the dorsolateral prefrontal cortex of the rhesus monkeyExperimental Neurology, 1970
- Analysis of frontal and posterior association syndromes in brain-damaged monkeys.Journal of Comparative and Physiological Psychology, 1952
- The function of the frontal cortex.Psychological Review, 1949