THE MECHANISM OF SYNERGISTIC ACTION OF DMC WITH DDT AGAINST RESISTANT HOUSE FLIES
Open Access
- 1 June 1953
- journal article
- other
- Published by University of Chicago Press in The Biological Bulletin
- Vol. 104 (3), 426-438
- https://doi.org/10.2307/1538495
Abstract
1. DMC has no insecticidal properties but markedly enhances the effectiveness of DDT against resistant house flies. The addition of a small amount of DMC causes a significant drop in the amount of DDT required for a given mortality. 2. Data interpolated from probit-log dosage lines for DDT alone and DDT plus DMC show that, under experimental laboratory conditions, the resistance of the Roberds strain can be markedly reduced. 3. Greatest synergistic effect is manifested when DMC and DDT are applied together, for separate application of the chemicals at 6-hour and 24-hour intervals shows a marked reduction in mortality. 4. DMC is rapidly metabolized by living flies and is excreted principally as a product tentatively identified as bis-(p-chlorophenyl) acetic acid (DDA). The compound 1,l-bis-(p-chlorophenyl) ethylene is suggested as being an intermediate product in DMC metabolism. 5. A correlation is shown between the extent of synergistic action and the degree of inhibition of DDT-detoxification in resistant flies. 6. Inhibition appears to be of a competitive type, the synergist competing with the insecticide for the mechanism of detoxification.Keywords
This publication has 10 references indexed in Scilit:
- Effects of DDT Upon the Respiration of Susceptible and Resistant House Flies1Journal of Economic Entomology, 1951
- SOME ASPECTS OF RESPIRATORY METABOLISM DURING METAMORPHOSIS OF NORMAL AND DDT-RESISTANT HOUSE FLIES, MUSCA DOMESTICA LThe Biological Bulletin, 1951
- Resistance of Houseflies to DdtNature, 1951
- A Comparison of the Cytochrome Oxidase Activity of Two Strains of House FliesJournal of Economic Entomology, 1950
- AN INVESTIGATION ON THE ACTION OF PIPERONYL BUTOXIDE WITH PYRETHRUMAmerican Journal of Epidemiology, 1950
- The Detoxification of DDT by Resistant Houseflies and Inhibition of This Process by Piperonyl CycloneneScience, 1950
- BIOASSAY SYSTEMS FOR THE PYRETHRINS IIAnnals of Applied Biology, 1949
- Pre-treating House Flies with Synergists Before Applying Pyrethrum SpraysJournal of Economic Entomology, 1947
- Colorimetric Determination of DDT.Color Test For Related CompoundsIndustrial & Engineering Chemistry Analytical Edition, 1945
- Activation of Pyrethrins by Sesame OilNature, 1944