Lithium-Sensitive Production of Inositol Phosphates During Amphibian Embryonic Mesoderm Induction
- 10 April 1992
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 256 (5054), 243-245
- https://doi.org/10.1126/science.1314424
Abstract
Mesoderm induction and body axis determination in frog (Xenopus) embryos are thought to involve growth factor-mediated cell-cell signaling, but the signal transduction pathways are unknown. Li+, which inhibits the polyphosphoinositide (PI) cycle signal transduction pathway in many cells, also disrupts axis determination and mesoderm induction. Amounts of the PI cycle-derived second messenger, inositol 1,4,5-trisphosphate, increased during mesoderm induction in normal embryos; addition of Li+ inhibited the embryonic inositol monophosphatase and reversed this increase. Embryonic PI cycle activity thus shows characteristics that indicate it may function in mesoderm induction and axis determination.Keywords
This publication has 27 references indexed in Scilit:
- Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequencesTrends in Pharmacological Sciences, 1991
- Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryosCell, 1991
- Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structuresCell, 1990
- Neural and developmental actions of lithium: A unifying hypothesisCell, 1989
- The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm InducerScience, 1988
- The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryosDevelopmental Biology, 1988
- Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryoCell, 1987
- Mesoderm induction in early Xenopus embryos by heparin-binding growth factorsNature, 1987
- Lithium-induced respecification of pattern in Xenopus laevis embryosNature, 1986
- Early cellular interactions promote embryonic axis formation in Xenopus laevisDevelopmental Biology, 1984