Histoplasmosis is a fungus infection, the primary focus of which is usually in the lung.18 Though the disease has world-wide distribution, the majority of cases have been reported in the United States in the area generally referred to as the Mississippi Valley. The pulmonary disease is commonly self-limited and is symptomless in most cases. However, progressive pulmonary and extrapulmonary disease can occur. Of extrapulmonary foci the skin and mucosal are among the most frequently noted. Though the incidence of secondary cutaneous lesions is not in the same range as is noted in North American blastomycosis, the presence of histoplasmosis of the mucosae of the gastrointestinal tract beginning with the mouth and ending with the rectum has become a well-recognized syndrome, especially in patients aged 40 and over. Miller et al.11 in 1947 reviewed 88 cases of active dissemination of the disease, 45 of which had