Nerve Growth Factor Effect on Adenosine Transport in Cultured Chromaffin Cells
- 1 January 1987
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 48 (1), 233-235
- https://doi.org/10.1111/j.1471-4159.1987.tb13152.x
Abstract
Chromaffin cells both recently isolated or in culture present a high-affinity adenosine transporter with a Km value of 1 .mu.M. When cells were exposed to nerve growth factor (NGF; 10 ng/ml), the adenosine transporter affinity decreased to 3 .mu.M. This value was maintained from 3 days after plating to the end of the culture period. A change in the transport capacity was observed, with a significant increase (.apprx. 200-260%) in NGF-cultured cells throughout the period studied.Keywords
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