The radiobogic and clinical features of 28 cases of melanomas of the central nervous system are described. The combination of the following features should suggest the diagnosis of an intracerebral melanoma: (1) Rapid increase in size ofa known intracerebral lesion; (2) a space occupying intracerebral lesion associated with subarachnoid hemorrhage; and (3) a case with known peripheral melanoma [See figure in the PDF file] in which a cerebral lesion is found with angioarchitecture suggestive of a meningioma.