Controls of RNA splicing and termination in the major late adenovirus transcription unit
- 1 July 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 292 (5822), 420-426
- https://doi.org/10.1038/292420a0
Abstract
The major late adenovirus promoter is active early after infection, selectively producing mRNA coding for polypeptides with MW of 55,000, 52,000 and 14,000. This selective expression suggests that a differential splicing pattern occurs at the transition from early to late viral gene expression. Activation of the late promoter and splicing of the 55,000 and 52,000 mRNA does not require newly synthesized virus polypeptides.Keywords
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