Dopamine Metabolism and Receptor Function After Acute and Chronic Ethanol
- 1 July 1980
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 35 (1), 34-37
- https://doi.org/10.1111/j.1471-4159.1980.tb12486.x
Abstract
Acute ethanol treatment in rats elicits a selective increase in dihydroxyphenylacetic acid (DOPAC) content in striatum. In contrast, striatal DOPAC concentration does not differ from normal values after chronic ethanol treatment. Chronic administration of ethanol however causes a selective increase of specific [3H] spiroperidol binding and Met-enkephalin content in the striatum. Kinetic analysis of [3H] spiroperidol binding data shows that after chronic ethanol treatment there is a significant increase in the affinity constant rather than in the number of binding sites for the ligand. Dopaminergic mechanisms at both pre- and postsynaptic level may be involved in the mediation of some of the central effects observed after ethanol consumption.Keywords
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