Conformational analysis of 6-cis- and 6-trans-leukotriene B4-calcium complexes.
- 1 June 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (11), 3370-3374
- https://doi.org/10.1073/pnas.81.11.3370
Abstract
A computational description of the conformation of a pair of 2 isomeric molecules (6-cis- and 6-trans-leukotriene B4) forming a complex with 1 Ca ion is presented. The theoretical prediction of the membrane-water interface conformation and of the bulk lipid phase conformation of the 2 different isomeric complexes is in excellent agreement with experimental data on the leukotriene-mediated Ca ionophoresis in liposomes. The 2 isomers lead to vastly different conformations in the presence of Ca2+, and the most probable conformation of the permeant species shows a globular conformation able to cross a lipid membrane.This publication has 26 references indexed in Scilit:
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