Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
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Open Access
- 1 January 2001
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 76 (1), 173-181
- https://doi.org/10.1046/j.1471-4159.2001.00012.x
Abstract
Converging lines of evidence implicate the beta-amyloid peptide (Aβ) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce Aβ production by functionally inhibiting γ...Keywords
This publication has 37 references indexed in Scilit:
- Distinct Secretases, a Cysteine Protease and a Serine Protease, Generate the C Termini of Amyloid β‐Proteins Aβ1‐40 and Aβ1‐42, RespectivelyJournal of Neurochemistry, 1999
- Amyloid β-peptide induces apoptosis-related events in synapses and dendritesBrain Research, 1998
- Effects of Specific Protease Inhibitors on Amyloid β-Protein 42 SecretionNeurobiology of Aging, 1998
- Amyloid β-protein toxicity and oxidative stress in Alzheimer's diseaseCell and tissue research, 1997
- Lipid-lowering trials in the primary and secondary prevention of coronary heart disease: new evidence, implications and outstanding issuesCurrent Opinion in Lipidology, 1996
- Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In VivoNeuron, 1996
- The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐ProteinaAnnals of the New York Academy of Sciences, 1996
- Cells with a familial Alzheimerʼs disease mutation produce authentic β-peptideNeuroReport, 1993
- Isolation and quantification of soluble Alzheimer's β-peptide from biological fluidsNature, 1992
- Amyloid β-peptide is produced by cultured cells during normal metabolismNature, 1992