The effects of moisture content and gelatin binding agent on the mechanical and failure properties of an Oxytetracycline formulation

Abstract

N PILPEL A study has been made of the effects of gelatin as a binding agent and of moisture content on the mechanical and failure properties of an oxytetracycline tablet formulation, using measurements of the shear strengths and tensile strengths. As the concentration of gelatin at any moisture level between 0 and 25 % w/w is increased, the tensile strength of the formulation increases. Its cohesion and angle of internal friction also increase with gelatin concentration at moisture levels between 2 and 4% w/w. The results are discussed in the light of current theories concerning the bonding of particles by moisture and binding agents.