Paraneoplastic Encephalomyelitis Antigens Bind to the AU-rich Elements of mRNA
- 1 March 1995
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 45 (3), 544-550
- https://doi.org/10.1212/wnl.45.3.544
Abstract
Article abstract-The Hu antigens are composed of a family of neuronal-specific, RNA-binding proteins encoded by at least three distinct genes. All three gene products, HuD, HuC/ple21, and Hel-N1, are human homologues of Elav, a Drosophila protein required for neuronal development and maintenance. Although the three proteins are very similar in structure, they are differentiated by alternative splicing of their mRNAs. We report here that the Hu antigens bind avidly to the AU-rich element resident in many mRNAs that regulate cell proliferation. This interaction suggests that the Hu antigens promote neuronal differentiation by suppressing the neuroblast cell cycle. Such a mechanism provides a plausible model for the role of the Hu antigens in tumorigenesis, neuronal differentiation, and paraneoplastic neurologic disorders. NEUROLOGY 1995;45: 544-550Keywords
This publication has 14 references indexed in Scilit:
- Neurologic paraneoplastic antibodies (anti‐Yo; anti‐Hu; anti‐Ri)Neurology, 1994
- The Streptococcus pyogenes Hyaluronan Synthase: Sequence Comparison and Conservation among Various Group A StrainsBiochemical and Biophysical Research Communications, 1994
- Claustrin, an antiadhesive neural keratan sulfate proteoglycan, is structurally related to MAP1BJournal of Neurobiology, 1994
- Europe's research after MaastrichtNature, 1993
- Message from the EditorAnnals of Neurology, 1993
- Anti-Hu-Associated Paraneoplastic Encephalomyelitis/Sensory Neuronopathy A Clinical Study of 71 PatientsMedicine, 1992
- On the production of neurologists in the United StatesNeurology, 1991
- Research and Development in South KoreaScience, 1988
- Duchenne muscular dystrophyNeurology, 1988
- DrosophilaMushroom Body Mutants are Deficient in Olfactory LearningJournal of Neurogenetics, 1985