Sensibilisation eczémateuse expérimentale au D. N. C. B. chez l’homme: comportement chez les malades cutanés et après ablation chirurgicale du foyer d’irritation primaire
Experimental sensitization (S) of eczematous type by contact with DNCB under various conditions was investigated in 276 subjects. The incidence of S, tested with a 2.5/5% DNCB solution in subjects with contact-type eczema or other types, did not offer notable differences in comparison to the healthy control group. The same findings resulted in subjects witn neo-plastic diseases. Several psoriatic patients showed a certain resistance to S. The mode of appearance and diffusion of S after surgical removal of the primary cutaneous focus of irritation, either by excising skin areas or by amputating the entire limb, i. e. in case of Buerger'' s disease, were also studied. When the operation was performed within 24 hour s after contact with the S agent, S did not appear. The phenomenon was observed, however, when the operation was performed 48 hours after contact. Furthermore, it is possible to obtain S by applying the allergen on large skin areas, without epithelium. However, it is difficult to exclude, in the latter case, the eventual contact of allergen with surrounding epithelial structures.