The transport of materials within the nervous system has received much attention in recent years. Considerable information has accumulated concerning such subjects as the exchange of substances between the circulation and nervous tissue, the passage down axons of molecules and organelles originating in perikarya and the release and fate of neurotransmitters and neurosecretory agents at synapses and other neuron endings (see, for example, Wolstenholme & Porter 1968; Barondes 1969). Many investigations are underway on modulations of transport during nerve growth and regeneration and in tissue responding to injury or to other experimental alterations. However, numerous gaps remain. Of central importance to future analysis of intraneuronal transport will be the determination of details of the routes and mechanisms by which various components synthesized in the perikaryon become distributed throughout the cell. It is becoming increasingly clear that different components move along axons at quite different rates (see, for example, McEwen & Grafstein 1968). This heterogeneity may reflect the existence of a variety of intraaxonal transport pathways. Important clues derive from such work as the studies on microtubules reported by D. S. Smith in the present proceedings but much remains to be learned about possible compartmentalization of movement within axons. Similarly, the organization of perikarya must be further investigated. Neurons possess abundant rough endoplasmic reticulum, many free ribosomes, a well-developed Golgi apparatus and other features consonant with their intensive metabolic activity. Remarkably little is known, however, about most of the molecules synthesized within perikarya and about the division of labour among the organelles of the perikaryal cytoplasm.