A Highly Sensitive HPLC Method to Discriminate Enantiomeric Amino Deoxy Sugars Based on the Derivatization With (S) - (+)-Tbmb Carboxylic Acid
- 1 February 1996
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 15 (2), 217-230
- https://doi.org/10.1080/07328309608005440
Abstract
A picomole determination of the absolute configurations of amino deoxy sugars was demonstrated through the derivatization at the anomeric carbon with a fluorescent chiral reagent, (S)-(+)-TBMB carboxylic acic, followed by the HPLC separations of the derived diastereomeric isomers. A new chemical procedure was developed to convert amino deoxy sugars into per-NH,O-acetylated glycosyl chlorides prior to derivatization with the reagent.Keywords
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