Tables of the number of patients required in clinical trials using the logrank test
- 1 January 1982
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 1 (2), 121-129
- https://doi.org/10.1002/sim.4780010204
Abstract
The logrank test is commonly used in the analysis of clinical trials in chronic diseases such as cancer. Existing tables for the number of patients required in such trials are based on the direct comparison of two proportions. This paper presents tables of numbers required in clinical trials using the logrank test and describes their use. The numbers required are considerably smaller than those in existing tables when the event-free proportions are small, but otherwise comparable.Keywords
This publication has 8 references indexed in Scilit:
- Introduction to sample size determination and power analysis for clinical trialsControlled Clinical Trials, 1981
- The asymptotic properties of nonparametric tests for comparing survival distributionsBiometrika, 1981
- RANDOMISED COMPARATIVE STUDIES IN THE TREATMENT OF CANCER IN THE UNITED KINGDOM: ROOM FOR IMPROVEMENT?The Lancet, 1979
- Size of cancer clinical trials and stopping rulesBritish Journal of Cancer, 1978
- The Power Function of the "Exact" Test for Comparing Two Binomial DistributionsJournal of the Royal Statistical Society Series C: Applied Statistics, 1978
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examplesBritish Journal of Cancer, 1977
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and designBritish Journal of Cancer, 1976
- Planning the size and duration of a clinical trial studying the time to some critical eventJournal of Chronic Diseases, 1974