Regulation of calcium influx by second messengers in rat mast cells
- 1 August 1988
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 334 (6182), 499-504
- https://doi.org/10.1038/334499a0
Abstract
Biphasic increases in the free intracellular calcium concentration, consisting of a large initial transient followed by a sustained elevation, are frequently observed in non-excitable cells following stimulation. In rat peritoneal mast cells a cAMP- and Ca-activated chloride current can interact with IP3-dependent calcium influx to provide the sustained elevation of intracellular Ca concentration following transient IP3-induced release of calcium from intracellular stores. This novel combination of second messenger systems provides a flexible means to modulate calcium-dependent processes such as exocytosisKeywords
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