Prolonged Corticotrophic Action of a Synthetic Substituted 1-18 ACTH
- 25 September 1971
- Vol. 3 (5777), 742-743
- https://doi.org/10.1136/bmj.3.5777.742
Abstract
The adrenocorticotrophic effects of a synthetic corticotrophin analogue, α1-18 ACTH with D-serine1, lysine17, and lysine amide18 substitutions has been studied. It is effective after both intramuscular and subcutaneous administration and compared with tetracosactrin depot (Synacthen depot, Cortrosyn depot) it has a similarly prolonged time course of action—about 24 hours after 0·5 mg and 30 hours after 1 mg. Unlike tetracosactrin depot, however, it is well absorbed when given intranasally and does not produce painful reactions at the site of injection. Its prolonged time course of action does not depend on a formulation designed to delay its release from the injection site but most probably on a decreased rate of degradation in the circulation.Keywords
This publication has 9 references indexed in Scilit:
- Comparison of depot tetracosactrin and corticotrophin gelBMJ, 1969
- [Treatment of bronchial asthma using a synthetic beta 1-18 corticotropin derivative].1969
- Administration by nasal spray of an 18 amino acid synthetic polypeptide with corticotropic actionCellular and Molecular Life Sciences, 1969
- Allergic intolerance to tetracosactrin.BMJ, 1969
- Assessment of Long-acting Synthetic Corticotrophin in Hypersensitive Asthmatics and Normal SubjectsBMJ, 1968
- Adrenocorticotrophic action of long-acting tetracosactrin compared with corticotrophin-gelBMJ, 1967
- Adrenocorticotropic Effects of a Synthetic Polypeptide—β1–24-Corticotropin—in ManJournal of Clinical Endocrinology & Metabolism, 1964
- A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasmaJournal of Clinical Pathology, 1962
- Proposed System of Terminology for Preparations of Adrenocorticotropic HormoneScience, 1959