Cobalt(II) Catalyzed Coupling Reaction of α,β-Unsaturated Compounds with Aldehydes by the Use of Phenylsilane. New Method for Preparation of β-Hydroxy Nitriles, Amides, and Esters

Abstract

A new crossed coupling reaction of α,β-unsaturated nitriles with aldehydes was performed by using phenylsilane and a catalytic amount of bis(1,3-diketonato)cobalt(II) to give β-siloxy nitriles in good yields. Similarly, α,β-unsaturated amides and esters also reacted under the same conditions to afford β-siloxy amides or esters. The present reaction provides a new and facile method for preparation of β-hydroxy nitriles, amides, and esters.