Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Top Cited Papers
Open Access
- 1 November 2006
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 20 (21), 2913-2921
- https://doi.org/10.1101/gad.1467506
Abstract
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1–7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.Keywords
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