Gastrointestinal microbleeding after aspirin and naproxen

Abstract

Gastrointestinal bleeding is the most serious side effect encountered with the anti-inflammatory antirheumatic drugs. Using the ⁵¹Cr labeling technique, the comparative quantity of blood loss with aspirin or naproxen has been previously done on normal volunteers. With the present study, 12 rheumatoid arthritic patients were controlled in a double-blind crossover study with the same radioactive technique. There is a difference in favor of naproxen. The difference between the baseline period and naproxen administration was not statistically significant.