THE EFFECT OF INDOMETHACIN ON SPONTANEOUS ACTIVITY IN THE ISOLATED HUMAN MYOMETRIUM AND ON THE RESPONSE TO OXYTOCIN AND PROSTAGLANDIN
- 1 January 1978
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 85 (1), 47-52
- https://doi.org/10.1111/j.1471-0528.1978.tb15825.x
Abstract
The spontaneous activity of human myometrial strips obtained during the proliferative and secretory phases of the menstrual cycle and during the early and late stages of pregnancy was studied. Both prostaglandin F2α (PGF2α) and oxytocin caused contractions which were superimposed on a low level of spontaneous activity but only PGF2α was seen to affect high levels of activity. Spontaneous contiactions were ultimately abolished by the addition of indomethacin. The strips remained responsive to PGF2α but not to oxytocin.Keywords
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