Dose-response: variation with age, sex, and health status

Abstract

WILMORE, J. H. Dose-response: variation with age, sex, and health status. Med. Sci. Sports Exerc., Vol. 33, No. 6, Suppl., 2001, pp. S622–S634. The purpose of this study was to summarize the literature on the influence of age, sex, and health status on the changes in systolic (SBP) and diastolic blood pressure (DBP), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) consequent to exercise training. A MEDLINE search was performed from January 1966 through August 2000 to identify studies that have investigated the effects of age, sex, and health status on the changes in the outcome variables with exercise training. References from these studies and from review and meta-analysis studies were also reviewed. The results indicate that age has little or no influence on the changes in SBP, DBP, TG, and HDL-C in response to exercise training. When looking at sex, females appear to have an attenuated response to exercise training compared with males with respect to SBP, DBP, and HDL-C, but the data for TG are equivocal. Finally, there appears to be more favorable changes in resting SBP and DBP, TG, and HDL-C in unhealthy subjects (hypertensive and post-MI patients) when compared with healthy subjects.