INHERITANCE OF HIGH LEUKOCYTE FOLATE BINDING-ACTIVITY - RELATIONSHIP BETWEEN FOLATE BINDING IN LEUKOCYTES AND SERUM

Abstract

Folate binding was determined in leukocyte lysates from relatives of 3 persons whose leukocytes contained large amounts of folate binding protein. A pedigree analysis showed that high leukocyte folate binding activities occurred with great frequency in these families, suggesting a dominant mode of inheritance. Folate binding in serum varied within narrow limits (0.2-0.5 nmol folate/l serum) in persons with leukocyte folate binding activities less than 0.8-1.0 nmol folate/109 cells. A shift to a higher level of serum folate binding (.gtoreq. 1.0 nmol/l serum) was, however, observed at leukocyte folate binding activities above that value.