‘One-pot’ biomimetic synthesis of 19β-heteroyohimbine alkaloids

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Abstract
Tryptamine and secologanin have been converted into akuammigine (7b), tetrahydroalstonine (7a), and ajmalicine (7c), in a highly regio- and stereo-selective sequence of reactions which duplicates the in vivo process; strictosidine (6a) is a precursor for 3α-alkaloids and vincoside (6b) for 3β.