In July 1933 a new routine for the treatment of patients with tetanus was introduced into the Cook County Hospital. In a previous publication1 the rationale of this method of management has been discussed. This paper will be devoted to a description of the treatment employed and to a statistical analysis of the results noted in the care of 96 patients (referred to as the new series) managed according to the new routine during the seven year period ending in July 1940. Included as a basis for comparison is a discussion of the observations made from a detailed review of the hospital records of 180 patients (designated as the old series) treated according to the older routine during an eleven year period which preceded the introduction of the present method of management. Likewise, the general trend of the mortality from tetanus at Cook County Hospital has been reviewed for