Lung clearance of soluble radioaerosols of different molecular weights in systemic sclerosis.
Open Access
- 1 February 1979
- Vol. 34 (1), 63-67
- https://doi.org/10.1136/thx.34.1.63
Abstract
Clearance rates of soluble radioaerosols of sodium pertechnetate (99mTcO4; mol wt 163) and diethylenetriaminepenta-acetate (99mTc-DTPA; mol wt 492) were determined in seven normal subjects and ten patients with systemic sclerosis affecting the lungs. Twenty millicuries (mCi) each of 99mTcO4 and 99mTc-DTPA in 5 ml saline were aerosolised and inhaled using a disposable "Blount" nebuliser on two different days. Two regions of interest over each posterior lung field were monitored with scintillation camera, and data were stored on magnetic tape using a Hewlett Packard Data Analyser. Decreasing levels of radioactivity were plotted semilogarithmically and half-time (T 1 1/2) removal rates were calculated. The T 1 1/2) values in normal subjects did not differ significantly from T 142 values of the patients with TcO4. However, the removal rates of the higher molecular weight solute were significantly faster from lower lung zones in patients with systemic sclerosis than in the normal subjects. The faster absorption of DTPA from lower lung zones of the patients could be due to regional abnormalities of alveolar epithelium at the lung bases, presumably as a result of greater retractive forces secondary to fibrosis.This publication has 9 references indexed in Scilit:
- Small airways in progressive systemic sclerosis (PSS)American Journal Of Medicine, 1979
- IMAGING SMALL PULMONARY ISCHEMIC LESIONS AFTER RADIOACTIVE CARBON-MONOXIDE INHALATION1976
- The ultrastructure of pulmonary lymphatic capillaries of newborn rabbits and of human infants.1969
- Pulmonary lymphatic and blood absorption of albumin from alveoli. A quantitative comparison.1969
- Previous volume history of the lung and regional distribution of gas.Journal of Applied Physiology, 1968
- Electron microscopic study of lymphatic capillaries in the removal of connective tissue fluids and particulate substances.1968
- A STUDY OF PARTICULATE CLEARANCE FROM HUMAN LUNGSPublished by Elsevier ,1967
- Regional distribution of inspired gas in the lung.Journal of Applied Physiology, 1966
- AN ELECTRON MICROSCOPIC STUDY OF INJURED AND ABNORMALLY PERMEABLE LYMPHATICSAnnals of the New York Academy of Sciences, 1964