NOTE ON THE EFFECTS OF THYROIDECTOMY AND THYROID HORMONE ADMINISTRATION ON THE CONCENTRATION OF BILE CHOLESTEROL AND CHOLIC ACID

Abstract

SUMMARY: The diminished cholesterol concentration in bile obtained after thyroidectomy, previously demonstrated by Rosenman, Friedman & Byers [1951], has been confirmed, but an increased concentration after chronic administration of triiodothyronine (T₃) or triiodothyroacetic acid (TA₃) could not be demonstrated. The blood and bile cholesterol concentrations were not affected by large single doses of T₃ or TA₃. Secretion of biliary cholic acid was reduced after thyroidectomy and by prolonged administration of T₃ or TA₃. A low iodine diet had the same effect as thyroidectomy on the concentrations of bile cholesterol and cholic acid.